Detalhe da pesquisa
1.
Comparative chemical and biological hydrolytic stability of homologous esters and isosteres.
J Enzyme Inhib Med Chem
; 37(1): 718-727, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35156494
2.
Novel phosphatidylinositol 4-kinases III beta (PI4KIIIß) inhibitors discovered by virtual screening using free energy models.
J Comput Aided Mol Des
; 34(10): 1091-1103, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32601839
3.
Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant.
J Enzyme Inhib Med Chem
; 34(1): 631-637, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30727776
4.
Synthesis and biological evaluation of N-aryl-2-phenyl-hydrazinecarbothioamides: Experimental and theoretical analysis on tyrosinase inhibition and interaction with HSA.
Bioorg Chem
; 81: 79-87, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30118988
5.
An Unusual Intramolecular Halogen Bond Guides Conformational Selection.
Angew Chem Int Ed Engl
; 57(31): 9970-9975, 2018 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29873877
6.
Fluorescence and Docking Studies of the Interaction between Human Serum Albumin and Pheophytin.
Molecules
; 20(10): 19526-39, 2015 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26516829
7.
A novel 3,9-(1,2,3-trioxocine)-type steroid of Rauia nodosa (Rutaceae).
Molecules
; 19(9): 14637-48, 2014 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25230120
8.
Investigation of trypanothione reductase inhibitory activity by 1,3,4-thiadiazolium-2-aminide derivatives and molecular docking studies.
Bioorg Med Chem
; 20(5): 1760-6, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22304847
9.
Solvent-free synthesis, DNA-topoisomerase II activity and molecular docking study of new asymmetrically N,N'-substituted ureas.
Molecules
; 17(11): 12882-94, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23117429
10.
Molecular Modeling Techniques Applied to the Design of Multitarget Drugs: Methods and Applications.
Curr Top Med Chem
; 22(5): 333-346, 2022 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34844540
11.
Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-arylpiperazine Derivatives Characterized as D2/D3 Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases.
Biomolecules
; 12(8)2022 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36009006
12.
Methyl Effect on the Metabolism, Chemical Stability, and Permeability Profile of Bioactive N-Sulfonylhydrazones.
ACS Omega
; 7(43): 38752-38765, 2022 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36340078
13.
A novel scaffold for EGFR inhibition: Introducing N-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives.
Sci Rep
; 9(1): 14, 2019 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30626888
14.
Regioselective microwave synthesis and derivatization of 1,5-diaryl-3-amino-1,2,4-triazoles and a study of their cholinesterase inhibition properties.
RSC Adv
; 9(35): 20356-20369, 2019 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35514684
15.
5-Enolpyruvylshikimate-3-phosphate synthase: determination of the protonation state of active site residues by the semiempirical method.
Bioorg Chem
; 36(3): 113-20, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18325563
16.
Multi-Spectroscopic and Theoretical Analysis on the Interaction between Human Serum Albumin and a Capsaicin Derivative-RPF101.
Biomolecules
; 8(3)2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30142945
17.
Novel piperonal 1,3,4-thiadiazolium-2-phenylamines mesoionic derivatives: Synthesis, tyrosinase inhibition evaluation and HSA binding study.
Int J Biol Macromol
; 112: 1062-1072, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-29447969
18.
Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-N-Acylhydrazone Derivative.
Pharmaceuticals (Basel)
; 11(4)2018 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30388818
19.
Structure-Based Discovery of Thiosemicarbazone Metalloproteinase Inhibitors for Hemorrhage Treatment in Snakebites.
ACS Med Chem Lett
; 8(11): 1136-1141, 2017 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29152044
20.
New potent 5-nitrofuryl derivatives as inhibitors of Trypanosoma cruzi growth. 3D-QSAR (CoMFA) studies.
Eur J Med Chem
; 41(4): 457-66, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16497414